Delima, Enggar Mareth (2019) Effect of Interval and Continuous Training on Proliferator‑Activated Receptor Gamma Coactivator‑1α and Lactate Dehydrogenase B Levels in Adult Rat Heart. Journal of Natural Science, Biology and Medicine, 10 (1). pp. 140-143. ISSN 0976-9668
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Abstract
Introduction: Mitochondrial biogenesis is affected by peroxisome proliferator‑activated receptor gamma coactivator‑1α (PGC‑1α) and can be induced through physical exercise. Lactate from the skeletal muscle produced in the heart during exercise can be used as an energy source through conversion by lactate dehydrogenase B (LDH B). This study compared the effects of continuous training (CT) and interval training (IT) on PGC‑1α and LDH B levels in the adult rat hearts. Materials and Methods: Fifteen male adult Wistar rats (12 months old) were randomly divided into three groups as follows: A control Group (c), a CT group and an IT group. Training was conducted using a rodent treadmill, 5 days/week for 8 weeks. The duration was 50 min for the CT group. In the IT group, training consisted of 4 bouts of 4 min of exercise, followed by rest intervals of 1 min. Speed was increased each week. After 8 weeks of training, the rats were sacrificed, and the levels of PGC‑1α and LDH B in heart tissue were measured using enzyme‑linked immunosorbent assay. Results: Differences in PGC‑1α levels between groups were statistically significant (P = 0.008), while differences in LDH B levels were not statistically significant (P = 0.063). Levels of PGC‑1α and LDH B were higher in the CT group than in the IT group. Conclusion: We concluded that CT has a greater effect on energy metabolism in the heart than IT.
| Item Type: | Article |
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| Uncontrolled Keywords: | Continuous training, heart, interval training, lactate dehydrogenase B, proliferator‑activated receptor gamma coactivator‑1α |
| Subjects: | 500 Sains dan Matematika > 570 Biologi, Ilmu Hayat > Biologi |
| Depositing User: | PPS Pasca Sarjana |
| Date Deposited: | 11 Aug 2020 06:31 |
| Last Modified: | 11 Aug 2020 06:31 |
| URI: | http://repository.radenfatah.ac.id/id/eprint/7269 |
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